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GSK-3β inhibitor 1

CAS No. 187325-53-7

GSK-3β inhibitor 1( —— )

Catalog No. M22450 CAS No. 187325-53-7

GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.GSK-3β inhibitor 1(compound 3a) inhibits GSK-3β with IC50 4.19 nM.?In a cell-based assay 3a shows no significant leucocyte toxicity at 10 M and is moderately cytotoxic against A549 cells.?

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    GSK-3β inhibitor 1
  • Note
    Research use only, not for human use.
  • Brief Description
    GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.GSK-3β inhibitor 1(compound 3a) inhibits GSK-3β with IC50 4.19 nM.?In a cell-based assay 3a shows no significant leucocyte toxicity at 10 M and is moderately cytotoxic against A549 cells.?
  • Description
    GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.GSK-3β inhibitor 1(compound 3a) inhibits GSK-3β with IC50 4.19 nM.?In a cell-based assay 3a shows no significant leucocyte toxicity at 10 M and is moderately cytotoxic against A549 cells.?Compound 3a demonstrated high antidiabetic efficacy in obese streptozotocin-treated rats improving glucose tolerance at a dose of 50 mg/kg body weight thus representing an interesting lead for further optimization.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    PI3K/Akt/mTOR signaling
  • Target
    GSK-3
  • Recptor
    GSK-3β
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    187325-53-7
  • Formula Weight
    222.24
  • Molecular Formula
    C14H10N2O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 30 mg/mL?(134.99 mM;?Need ultrasonic)
  • SMILES
    O=C1Nc2ccccc2\C1=C\c1ccccn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Lozinskaya NA, et al. Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors. Bioorg Med Chem. 2019 May 1;27(9):1804-1817.
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